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Department of Entomology, National Taiwan University

Core Faculty

Professor Chun-Che Chang
  • 發布單位:Department of Entomology

Research interests:

Insect Molecular Biology, Insect Developmental Biology, Insect Molecular Reproduction, Evolution and Development



Lab: Laboratory for Genomics and Development

Tel: +886-2-3366-5578; +886-2-2736-9366 (fax)



1996 - 2001, Ph.D. Department of Genetics & Wellcome/CRC Institute, University of Cambridge, U.K.

1990 - 1992, MSc. Graduate Institute of Biological Chemistry, National Taiwan University (NTU)

1987 - 1990, B.S. Department of Agricultural Chemistry, NTU

1986 - 1987, Freshman Department of Plant Pathology and Entomology, NTU



2016.8 - 2019.7 Chairman (Department of Entomology, NTU)

2014.8 - present Professor, NTU

2009.8 - 2014. 7 Associate professor, NTU

2003.8. - 2009. 7 Assistant professor, NTU

2002-2003 Postdoctoral Fellow, Institute of Molecular Biology, Academia Sinica

1994 Second Place, National Examination for the Qualification of Forensic DNA Scientists

1994 First Grade, Governmental Scholarship for Postgraduate Studies Overseas



  1. Germline Development
  2. Formation of the egg polarity and the determination of the body axes
  3. Molecular Biology of the Cell
  4. Developmental Diversity
  5. Genomics (mainly in the pea aphid)
  6. Project Management for Laboratory Scientists



  1. Molecular biology
  2. Genetics
  3. Project management for laboratory scientists
  4. DNA and developmental diversity
  5. Current topics on germline development
  6. Insect Biotechnology
  7. Essential Entomology
  8. Direct research of Biotechnology
  9. Seminar of Integrative Biology
  10. Modern technology and human civilization
  11. Ethics for engineers professionals
  12. Service learning (I) and (II)
  13. Direct research
  14. Thesis (B.S.)
  15. Thesis (M.S.)
  16. Thesis (Ph.D.)
  17. Freshmen Seminar


Publications of Chun-che Chang

Art editor Img

I. August 2009 – present

  • Lin, G.W., Chung, C.Y., Cook, C.E., Lai, M.D., Lee, W.C., and Chang, C-c.* (2022) Germline specification and axis determination in viviparous and oviparous pea aphids: conserved and divergent features. Development Genes and Evolution. 232:51-65. doi: 10.1007/s00427-022-00690-7. (invited review)
  • Panfilio, K. A., et al. (2019). "Molecular evolutionary trends and feeding ecology diversification in the Hemiptera, anchored by the milkweed bug genome." Genome Biology 20(1): 64. doi: 10.1186/s13059-019-1660-0.
  • Chung, C.Y., Hsiao, Y.M., Huang, T.Y., Chang, T.H., and Chang, C.-c. (2018). Germline expression of the hunchback orthologues in the asexual viviparous aphids: a conserved feature within the Aphididae. Insect Mol. Biol. 27, 752-765. doi: 10.1111/imb.12514.
  • Huang, T.Y., Chang, C-c., Cheng, N.C. Wang, M.H., Chiou, L.L., Lee, K.L., Lee, H.S.* (2017) Re-epithelialization of large wound in paedomorphic and metamorphic Axolotls. Journal of Morphology. 2017 Feb;278(2):228-235. doi: 10.1002/jmor.20631.
  • Lu, H.L., Chang, C-c., Wilson A.C.C.* (2016) Amino acid transporters implicated in endocytosis of Buchnera during symbiont transmission in the pea aphid. EvoDevo 7:24. doi: 10.1186/s13227-016-0061-7.
  • Chung, C.Y., Chang, C-c*, Lee, H.J.* (2016) Adaptation of the cockroach Blattella germanica to human habitats: circadian and noncircadian factors. Physiological Entomology, 41, 307–312. doi: 10.1111/phen.12163.
  • Wu, B.K., Yuan, R.Y., Chang, Y.P., Lien, H.W., Chen, T.S., Chien, H.C., Tong, T.S., Tsai, H.P., Fang, C.L., Liao Y.F., Chang, C-c*, Chen R.P.*, Huang C.J.* (2016) Epicatechin isolated from Tripterygium wilfordii extract reduces tau-GFP-induced neurotoxicity in zebrafish embryo through the activation of Nrf2. Biochem. Biophys. Res. Commun. 477: 283-289. doi: 10.1016/j.bbrc.2016.06.058.
  • Lin, G.W., Chang, C-c*. (2016) Identification of critical conditions for immunostaining in the pea aphid embryos: increasing tissue permeability and decreasing background staining. J. Vis. Exp. (108), e53883. doi:10.3791/53883.
  • Wu, B.K., Yuan, R.Y., Lien, H.W., Hung C.C., Hwang P.P., Chen R.P., Chang C-c.*, Liao, Y.F.*, Huang, C.J. * (2016) Multiple signaling factors and drugs alleviate neuronal death induced by expression of human and zebrafish tau proteins in vivo. J. Biomed. Sci. 23:25. doi: 10.1186/s12929-016-0237-4.
  • Lu, H.L., Price, D.R., Wikramanayake, A., Chang, C-c., Wilson, A.C.* (2016) Ontogenetic differences in localization of glutamine transporter ApGLNT1 in the pea aphid demonstrate that mechanisms of host/symbiont integration are not similar in the maternal versus embryonic bacteriome. EvoDevo 7:1. doi: 10.1186/s13227-015-0038-y.
  • Wang, S.C., Hsu, H.J., Lin, G.W., Wang, T.F., Chang, C-c.*, Lin, M.D.* (2015) Germ plasm localisation of the HELICc of Vasa in Drosophila: analysis of domain sufficiency and amino acids critical for localisation. Scientific Reports 5:14703. doi: 10.1038/srep14703.
  • Lin, G.W., Cook, C.E., Miura, T.*, and Chang, C-c.* (2014) Posterior localization of ApVas1 positions the preformed germ plasm in the sexual oviparous pea aphid Acyrthosiphon pisum. EvoDevo 5:18. doi:10.1186/2041-9139-5-18.
  • Chung, C.Y., Cook, C.E., Lin, G.W., Huang, T.Y., and Chang, C-c.* (2014) Reliable protocols for whole-mount fluorescent in situ hybridization (FISH) in the pea aphid Acyrthosiphon pisum: a comprehensive survey and analysis. Insect Science. doi: 10.1111/1744-7917.12086
  • Chung, C.Y., Chen, J.H., and Chang, C-c.* (2014) Appum, a Drosophila homolog of pumilio in the pea aphid: cloning, developmental expression, and presumptive roles in posterior patterning. Formosan Entomologist, 33: 237-252.
  • Hsiao, Y. M., Lin, G.W., and Chang, C-c.* (2014) Establishment of the pea aphid as a developmental model organism: history, significance, and future prospects (in Chinese). Formosan Entomologist, 33: 215-235.
  • Chang, C-c.*, Hsiao, Y.M., Huang, T.Y., Cook, C.E., Shigenobu, S.; Chang, T.H. (2013) Noncanonical expression of caudal during early embryogenesis in the pea aphid Acyrthosiphon pisum: maternal cad-driven posterior development is not conserved. Insect Molecular Biology, 22: 442–455. doi: 10.1111/imb.12035.
  • Lu, H.L., Tanguy, S., Rispe, C., Gauthier, J., Walsh, T., Gordon, K., Edwards, O., Tagu, D., Chang, C-c.*, Jaubert-Possamai, S.* (2011) Expansion of genes encoding piRNA-associated Argonaute proteins in the pea aphid: diversification of expression profiles in different plastic morphs. PLoS ONE 6(12): e28051. doi: 10.1371/journal.pone.0028051.
  • Huang, T.Y., Cook, C.E., Davis G.K., Shigenobu S., Chen R.P.-Y., and Chang C-c.* (2010) Anterior development in the parthenogenetic and viviparous form of the pea aphid, Acyrthosiphon pisum: hunchback and orthodenticle expression. Insect Molecular Biology 19: 75-85. doi: 10.1111/j.1365-2583.2009.00940.x.
  • Shigenobu S.*, Bickel, R.D., Brisson, J.A., Butts, T., Chang, C-c. et al. (2010) Comprehensive survey of developmental genes in the pea aphid, Acyrthosiphon pisum: frequent lineage-specific duplications and losses of developmental genes. Insect Molecular Biology 19: 47-62. doi: 10.1111/j.1365-2583.2009.00944.x.
  • The International Aphid Genomics Consortium (2010) Genome sequence of the pea aphid Acyrthosiphon pisum. PLoS Biology 8(2): e1000313. doi:10.1371/journal.pbio.1000313.
  • Chen, Y.C., Wu, B.C., Chu, C.Y., Cheng, C.H., Han, H.W., Chen, G.D., Lee, M.T., Hwang, P.P., Kawakami, K., Chang, C-c., and Huang, C.J.* (2010) Identification and characterization of alternative promoters of zebrafish Rtn-4/Nogo genes in cultured cells and zebrafish embryos. Nucleic Acids Research 38:4635-4650. doi: 10.1093/nar/gkq230.


II. August 2003~July 2009

  • Chang, C-c.*, Huang, T.Y., Cook, C.E., Lin, G.W., Shih, C.L., and Chen, R.P.-Y. (2009) Developmental expression of Apnanos during oogenesis and embryogenesis in the parthenogenetic pea aphid Acyrthosiphon pisum (Hemiptera: Aphidoidea). International Journal of Developmental Biology 53: 169-176. doi: 10.1387/ijdb.082570cc.
  • Tsai, Y.C., Solter, L.F., Wang, C.Y., Fan, H.S., Chang, C-c.*, and Wang, C.H.* (2009) Morphological and molecular studies of a microsporidium (Nosema sp.) isolated from the three spot grass yellow butterfly, Eurema blanda arsakia (Lepidoptera: Pieridae). Journal of Invertebrate Pathology 100: 85-93. doi: 10.1016/j.jip.2008.11.006.
  • Mito, T., Nakamura, T., Sarashina, I., Chang, C-c., Ogawa, S., Ohuchi, H., and Noji, T.* (2008) Dynamic expression patterns of vasa during embryogenesis in the cricket Gryllus bimaculatus. Development Genes Evolution 218: 381-387. doi: 10.1007/s00427-008-0226-z.
  • Chang, C-c.*, Huang, T.Y., Shih, C.L., Lin, G.W., Chang, T.P., Chiu, H., Chang, W.C. (2008) Whole-mount identification of gene transcripts in aphids: Protocols and evaluation of probe accessibility. Archives of Insect Biochemistry and Physiology 68: 186-96. doi: 10.1002/arch.20243.
  • Chang, C-c.*, Chiu, H., and Lee, H.J. (2008) Identification of nuage-like structures in the panoistic ovarioles of the German cockroach Blattella germanica (Linnaeus). Formosan Entomologist 28: 1-10.
  • Lin, G.W., Lu, S.L., Huang, T.Y., Shih, C.L., Wu, W.J.*, and Chang, C-c.* (2008) Molecular identification of weevils significant for customs inspection and quarantine importance. Formosan Entomologist 28: 43-55. (in Chinese)
  • Chang, C-c.*, Lin, G.W., Cook, C.E., Horng, S.B., Lee, H.J. and Huang, T.Y. (2007) Apvasa marks germ-cell migration in the parthenogenetic pea aphid Acyrthosiphon pisum (Hemiptera: Aphidoidea). Development Genes Evolution 217: 275–287. doi: 10.1007/s00427-007-0142-7.
  • Chang, C-c.*, Lee, W.C., Cook, C.E., Lin, G.W., and Chang, T. (2006) Germ-plasm specification and germline development in the parthenogenetic pea aphid Acyrthosiphon pisum: Vasa and Nanos as markers. International Journal of Developmental Biology 50: 413-421. doi: 10.1387/ijdb.052100cc.


III. Papers regarding the PhD thesis

  • Chang, C-c., Dearden, P., and Akam, M.* (2002) Germline development in the grasshopper Schistocerca gregaria: Vasa as a marker. Developmental Biology 252: 110-118. doi: 10.1006/dbio.2002.0840.
  • Chang, C-c. and Cook, C.E.* (2002) Trends in genomic “evo-devo". 3 (7): reports 4019.1-4019.2. Genome Biology. doi: 10.1186/gb-2002-3-7-reports4019.